2/21/2023 0 Comments Pe explorer 199 r6 serial key![]() Autoantigenic nucleic acids and their binding proteins are required for self-antigen specific activation of autoreactive lymphocytes. Īberrant innate immune responses play a significant role in the pathogenesis of SLE, contributing both to tissue injury via release of inflammatory cytokines as well as to aberrant activation of autoreactive T and B cells, with the latter leading to pathogenic autoantibody production and resultant end-organ injury (reviewed in ) ( Figure). The loss of tolerance with subsequent immune dysregulation is a consequence of genetic factors, in the setting of environmental triggers and stochastic events, with recent studies implicating over 30 genetic loci in disease pathogenesis (for recent reviews, see. ![]() SLE is characterized by production of pathogenic autoantibodies directed against nucleic acids and their binding proteins, reflecting a global loss of self-tolerance (reviewed in ). Systemic lupus erythematosus (SLE, or lupus) is a systemic autoimmune disease with multiorgan inflammation. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |